Probing and Regulating Dysfunctional Circuits Using Deep Brain Stimulation

Ventrolateral Preoptic Nucleus of Hypothalamus; A Possible Target for Deep Brain Stimulation for Treatment of Sexual Dysfunction

Sexual function and orientation is a complex platform of human personality which is being modulated by several brain circuities which is less understood currently. Recently, several studies have demonstrated interesting results regarding the role of several brain locations in sexual behaviors and orientation. Sexual arousal in homosexual men are associated with activation of the left angular gy...

Control of epileptic seizures by electrical low frequency deep brain stimulation: A review of probable mechanisms

Epilepsy is the most common neurological disease with no definitive method in treatment. Notably, the main way to treat and control epileptic seizures is drug therapy. However, about 20-30% of patients with epilepsy are drug resistant and require other therapeutic manners. Deep brain stimulation is a new therapeutic strategy for these patients. Conspicuously, there are no clear answers for basi...

O10: Deep Brain Stimulation and Psychiatry

The use of deep brain stimulation in psychiatric disorders has received great interest owing to the small risk of the operation, the reversible nature of the technique, and the possibility of optimizing treatment postoperatively. Currently deep brain stimulation in psychiatry is investigated for obsessive-compulsive disorder, Gilles de la Tourette’s syndrome and major depression. This presentat...

Deep Brain Stimulation and Gene Expression Alterations in Parkinson’s Disease

Treating refractory mental illness with closed-loop brain stimulation: Progress towards a patient-specific transdiagnostic approach.

Mental disorders are a leading cause of disability, morbidity, and mortality among civilian and military populations. Most available treatments have limited efficacy, particularly in disorders where symptoms vary over relatively short time scales. Targeted modulation of neural circuits, particularly through open-loop deep brain stimulation (DBS), showed initial promise but has failed in blinded...